A medical device and method of applying said medical device to deliver drugs and to remove thrombus or soft tissue clots from vascular or other lumens in a patient is presented. The medical device generally comprises an elongated tubular delivery member having a proximal portion and a distal portion that differ in rigidity and a leak-free connector that is in contact with the proximal portion of the delivery member and is compatible for use with fibrinolytic agents and application of a vacuum. The delivery member includes a metal core made out of multiple shaped-wire strands and a polymer overlay disposed about the core. The wire strands, which have both an A-side and a B-side, are helically wound to form a polygonal shaped lumen whose inner diameter is defined by the A-side of the strands.
