The invention concerns quinazoline derivatives of Formula (I) or apharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each ofX1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings definedhereinbefore in the description； processes for their preparation,pharmaceutical compositions containing them and their use in the manufactureof a medicament for use in the treatment of cell proliferative disorders or inthe treatment of disease states associated with angiogenesis and/or vascularpermeability.
