PROBLEM TO BE SOLVED: To provide an antipyretic analgesic composition that contains loxoprofen and caffeine and mitigates gastric mucosal injury.SOLUTION: An antipyretic analgesic composition contains (a) loxoprofen or salt thereof, (b) caffeine, and (c) one or more selected from the group consisting of carnauba wax, shellac, titanium oxide, talc and polyvinyl alcohol.