The medicine which becomes help for preventing the disease which the new piperazine derivative where this invention has the activity which adjusts the dopamine D3 receptor, is displayed with formula I, this stereoisomer, the salt for the medicine, the solvent dishes dressed with sauce, and the medicine composition which contains that kind of chemical compound, discloses these manufacturing, the parkinsons disease, the integrated malfunction symptom, is related to central nervous system obstacle such as medicine habit and medicine revolution or use, and kidney protection and the immunity adjustment of that kind of chemical compound for remedying, or in order to research the function of D3R and the disease which is related to D3R functional obstacleUse of that kind of chemical compound as is disclosed.本発明は、ドーパミンD3受容体を調節する活性を有する、式Iで表される新規ピペラジン誘導体、この立体異性体、医薬用塩、溶媒和物、及びそのような化合物を含有する医薬組成物、これらの調製を開示し、パーキンソン病、統合失調症、薬物嗜癖及び薬物回帰などの中枢神経系障害に関係する疾患の予防又は治療のためのそのような化合物の使用、並びに腎保護及び免疫調節のため、又はD3Rの機能及びD3R機能の障害に関係する疾患を研究するための助けとなる薬物としてのそのような化合物の使用を開示する。
