Michael Cicirelli,Neil S. Cutshall,Gregory A. Demopulos,George A. Gaitanaris,Alexander Gragerov,Thomas L. Little,Rene Onrust
申请号：
US16682665
公开号：
US20200276190A1
申请日:
2019.11.13
申请国别(地区):
US
年份:
2020
代理人:
摘要：
GPR174 is an orphan receptor that has been implicated in cancer, nervous system diseases and disorders and neuroregeneration. We have identified inhibitors of GPR174 and have identified the G-protein signaling pathways that GPR174 modulates. Based on this discovery, the present invention features methods for inhibiting GPR174 activity and thereby stimulating an immune response in a subject in need thereof, particularly in the use of treatment of non-malignant neoplasms, malignant neoplasms (i.e., cancer), nervous system diseases and disorders and neuroregeneration, as well as related compositions.
