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Compositions for inducing immune responses
专利权人:
Derek OHagan
发明人:
Derek OHagan,Manmohan Singh
申请号:
US12791020
公开号:
US08529906B2
申请日:
2010.06.01
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said first antigen is encapsulated within, adsorbed or conjugated to, co-lyophilized or mixed with said first adjuvant, and a pharmaceutically acceptable excipient, wherein said composition elicits a cellular immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions, methods for producing a cytotoxic-T lymphocyte (CTL) response in a vertebrate subject, and methods of immunization.
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