PROBLEM TO BE SOLVED: To provide a method that facilitates and enables early diagnosis of and clinical intervention in preeclampsia.SOLUTION: Provided are: a method for diagnosis of preeclampsia of a pregnant female mammal by detecting elevated levels of free hemoglobin, particularly free fetal hemoglobin, as biomarkers； and pharmaceutical compositions for prevention or treatment of preeclampsia containing &alpha；1-microglobulin.【課題】子癇前症の早期の診断及び臨床的介入が容易になり可能になる方法の提供。【解決手段】遊離ヘモグロビン(特に遊離胎児ヘモグロビン)の上昇レベルをバイオマーカーとして検出して、妊娠雌性哺乳動物の子癇前症を診断する方法、およびα1-ミクログロブリンを含んでなる子癇前症の予防又は治療用医薬組成物。【選択図】図１
