PEPTIDE AMÉLIORÉ INHIBITEUR DE L'ANGIOGENÈSE ET COMPOSITION POUR PRÉVENIR ET TRAITER UNE MALADIE ASSOCIÉE À L'ANGIOGENÈSE LE COMPRENANT EN TANT QUE PRINCIPE ACTIF
KIM, Young Myeong,BAEK, Yi Yong,PARK, Won Jin,KIM, Jeong Hun,JO, Dong Hyun
申请号：
EP16873185
公开号：
EP3388446A4
申请日:
2016.07.05
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present invention relates to improved peptides for inhibiting angiogenesis, Ac-RLYE and R (D) LYE, and a composition for the prevention and treatment of cancers and diseases related to angiogenesis comprising the peptides as an active ingredient. Specifically, the present invention relates to a peptide for inhibiting angiogenesis wherein the L-Arg of an N-terminal is acetylated in a peptide consisting of an amino acid sequence of Arg-Leu-Tyr-Glu, a peptide for inhibiting angiogenesis wherein L-Arg is substituted with D-Arg in a peptide consisting of the amino acid sequence of Arg-Leu-Tyr-Glu, and a method for using a composition comprising the peptides as active ingredients for the prevention or treatment of diseases (cancer, diabetic retinopathy or senile macular degeneration) caused by excessive angiogenesis. The peptides of the present invention have a long half-life and are excellent in VEGF-induced angiogenesis inhibitory effect. Therefore, the peptides developed in the present invention can be very effectively used for the prevention and treatment of diseases (cancer, diabetic retinopathy or senile macular degeneration) caused by excessive angiogenesis.
