LACTAM COMPOUNDS AS EP4 RECEPTOR-SELECTIVE AGONISTS FOR USE IN THE TREATMENT OF EP4-MEDIATED DISEASES AND CONDITIONS

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专利权人:

MYOMETRICS LLC;CAYMAN CHEMICAL COMPANY; INC.;CAYMAN CHEMICAL COMPANY, INC.

发明人:

BARRETT, STEPHEN, DOUGLAS,COLOMBO, JOSEPH, MICHAEL,GERMAIN, BRADLEE, DAVID,ENDRES, GREGORY, WILLIAM,KORNILOV, ANDRIY,KRAMER, JAMES, BERNARD,UZIEBLO, ADAM,CISKE, FRED, LAWRENCE,MAXEY, KIRK, M,O'MALLEY,,OMALLEY,

申请号：

PH12015502165

公开号：

PH12015502165A1

申请日:

2015.09.15

申请国别(地区):

PH

年份:

2016

代理人:

摘要：

Disclosed herein are compounds of formula (I) wherein L1, L2, L3, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.

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