CREWS, CRAIG,GUSTAFSON, JEFF,ROTH, ANKE, GUNDULA,TAE, HYUN, SEOP,BUCKLEY, DENNIS,NEKLESA, TAAVI
申请号:
EP13786919
公开号:
EP2846784A4
申请日:
2013.05.10
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention includes compounds that act as degraders of a target protein, wherein degradation is independent of the class of the target protein or its localization. In certain embodiments, the invention comprises a compound comprising a protein degradation moiety covalently bound to a linker, wherein the ClogP of the compound is equal to or higher than 1.5. In other embodiments, the target protein contemplated within the invention comprises a posttranslational modified protein or intracellular protein. In yet other embodiments, compounds of the present invention are used to treat disease states wherein protein degradation is a viable therapeutic approach, such as cancer or any sort of oxidative stress disease state.