Process for preparing FGF21 with low degree of O-glycosylation

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专利权人:

Rita Slaaby

发明人:

Rita Slaaby,Inger Lautrup-Larsen

申请号：

US13522804

公开号：

US09120871B2

申请日:

2011.01.20

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Expression of FGF21 in a S. cerevisiae pmt2 knock out strain reduces the O-glycosylation significantly and does not decrease the expression level. Expression in mkc7 knock out strain can decrease degradation of FGF21 and analogues thereof. Point mutations at position R17 and R36 can decrease degradation of FGF21 and analogues thereof when they are expressed in yeast.

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