PRATHER, Randall S.,WELLS, Kevin D.,WHITWORTH, Kristin M.
申请号：
AU2019257776
公开号：
AU2019257776A1
申请日:
2019.04.26
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
Livestock animals and offspring thereof comprising at least one modified chromosomal sequence in a gene encoding an aminopeptidase N (ANPEP) protein are provided. Animal cells that contain such modified chromosomal sequences are also provided. The animals, offspring, and cells have increased resistance to pathogens, including transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV). The animals, offspring, and cells can optionally further comprise at least one modified chromosomal sequence in a gene encoding a CD163 protein and/or a SIGLEC1 protein. Methods for producing pathogen-resistant non-human animals or lineages of non-human animals are also provided.
