Edward Weinstein,Xiaoxia Cui,Victoria Brown-Kennerly
申请号：
US12842943
公开号：
US20120023599A1
申请日:
2010.07.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding cytochrome P450 (CYP) proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequence encoding CYP proteins, as well as methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects.
