HAI-QUAN MAO,JOHN MICHAEL WILLIFORD,MAANI ARCHANG,IL MINN,YONG REN,JOSE LUIS SANTOS,MARTIN G. POMPER
申请号：
US15890771
公开号：
US20180177892A1
申请日:
2018.02.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compositions comprising a polymeric micellar nanoparticle composition comprising a block or graft copolymer comprising at least one polycationic polymer and at least one polyethylene glycol (PEG) polymer having an average molecular weight less than 1 kDa, and at least one nucleic acid, wherein the graft or block copolymer and at least one nucleic acid are complexed and condensed into a shaped micellar nanoparticle that is stable in biological media are disclosed. The presently disclosed subject matter also provides a method for preparing the presently disclosed polymeric micellar nanoparticle compositions, a method for targeting at least one metastatic cancer cell in a subject, and a method for treating a disease or condition using the presently disclosed polymeric micellar nanoparticle compositions.
