Miguel LOPEZ-TOLEDANO,Herbert WEISSBACH,Shailaja KESARAJU
申请号：
US15111954
公开号：
US20160340647A1
申请日:
2014.12.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Compositions and methods for inducing differentiation of stem cells such as cancer stem cells (CSCs), and increasing sensitivity of CSCs to at least one oxidizing agent in a subject include sulindac and/or epimers thereof. These sulindac-based compositions and methods are particularly useful for treating cancers such as glioblastoma (GBM) and for differentiating stem cells in vitro that can be used for cell replacement therapy in a subject in need thereof.
