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COMPOSITIONS AND PROCEDURES FOR TARGETING IN VITRO AND IN VIVO MEDICINE DELIVERY TO MAMMAL CELLS THROUGH BACTERIALLY DERIVATED INTAKE MINICELLS
专利权人:
EnGeneIC Molecular Delivery Pty Ltd
发明人:
BRAHMBHATT, Himanshu,MACDIARMID, Jennifer
申请号:
DK15162946
公开号:
DK2992901T3
申请日:
2005.01.27
申请国别(地区):
DK
年份:
2020
代理人:
摘要:
A composition comprising intact minicells that contain a drug molecule is useful for targeted drug delivery. One targeted drug delivery method employs bispecific ligands, comprising a first arm that carries specificity for a bacterially derived minicell surface structure and a second arm that carries specificity for a mammalian cell surface receptor, to target drug-loaded minicells to specific mammalian cells and to cause endocytosis of the minicells by the mammalian cells. Another drug delivery method exploits the natural ability of phagocytic mammalian cells to engulf minicells without the use of bispecific ligands.
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中国工程科技知识中心
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