The present invention includes macrocyclic prodrug compounds, pharmaceutical compositions containing them. The present invention also includes use of these compounds in the treatment of various diseases including an autoimmune disease, an inflammatory disease, a neurological or neurodegenerative disease, cancer, a cardiovascular disease, allergy, asthma, a hormone-related disease, and tumors or symptoms resulting from neurofibromatosis.Linvention concerne des composés de promédicaments macrocycliques, et des compositions pharmaceutiques contenant ces composés. Elle concerne également lutilisation de ces composés dans le traitement de diverses maladies, y compris des maladies auto-immunes, des maladies inflammatoires, des maladies neurodégénératives, le cancer, des maladies cardio-vasculaires, des allergies, lasthme, des maladies hormonales, et des tumeurs ou symptômes résultant de la neurofibromatose.
