Sulfoxides compounds Derivatives of 2 - (piperidin-1-yl) - dihidrotieno [3,2-d] pyrimidine Compounds； Preparation method； intermediaries； and use for treating allergic and inflammatory diseases such as COPD and Asthma.
The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.COMPUESTOS DERIVADOS DE SULFOXIDOS DE N-({2-PIPERIDIN-1-IL}-5OXO-6,7-DIHIDRO-5H-5 -TIENO[3,2-D]-PIRIMIDIN-4-IL)-CICLOBUTANO-1-AMINO, INHIBIDORES DE LA ENZIMA PDE4； COMPOSICION FARMACEUTICA； PROCEDIMIENTO DE PREPARACION； COMPUESTOS INTERMEDIARIOS； UTILES PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS O ALERGICAS DEL TRACTO RESPIRATORIO, TALES COMO EPOC O ASMA, TAMBIEN DEPRESION, ANSIEDAD, ESQUIZOFRENIA, ALZHEIMER, PARKINSON, ENTRE OTRAS.
