Of poorly water-soluble drug-containing particles bitterness such as water-soluble as well be improved and, while reducing as much as possible the addition of water-soluble components non-drug, which is an active ingredient, many of the poorly water-soluble drugs has has been masked I will provide a manufacturing method. In a fluidized bed granulator, the mixture having an average particle diameter contains 1 to 5 parts by weight of fluidizing agent and 100 parts by weight of poorly water-soluble drugs 100μm or less, an aqueous solution containing a water-soluble polymer of 1 to 10 wt% or that it was sprayed at a spray air velocity of 300~900m / sec hydroalcoholic solution, coating the 0.1 to 20 parts by weight of the solids weight of the water-containing alcohol solution or water-soluble polymer solution with respect to the mixture features a process for preparing particulate granules average particle diameter of 0.2 to 5 times the material slightly water-soluble drug.有効成分である水溶性薬物以外の添加成分を極力少なくしつつ、かつ水溶性が改善されるとともに、難水溶性薬物の多くが有している苦味等がマスキングされた難水溶性薬物含有粒子の製造法を提供する。流動層造粒装置において、平均粒子径が100μm以下の難水溶性薬物100重量部及び流動化剤1~5重量部を含有する混合物に、1~10重量%の水溶性高分子を含有する水溶液又は含水アルコール溶液を300~900m/secの噴霧空気速度で噴霧して、前記混合物に対して水溶性高分子溶液又は含水アルコール溶液中の固形分重量の0.1~20重量部をコーティングすることを特徴とし、平均粒子径が原料難水溶性薬物の0.2~5倍である微粒子造粒物の製造法。
