TECHNICAL UNIVERSITY OF DENMARK;NANOVI RADIOTHERAPY APS
发明人:
Thomas Andresen,Rasmus Irming Jølck,Linda Maria Bruun
申请号：
US16615504
公开号：
US20200222560A1
申请日:
2018.05.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Radiation therapy or radiotherapy (RT) is a powerful treatment where precision and accuracy is crucial. Image Guided Radiotherapy (IGRT) facilitates more accurate position verification, correcting for anatomic changes related to internal organ movement. IGRT thereby helps reduce toxicity of radiotherapy and increases relapse-free survival. An inter-correlation point with a fixed position and volume (a marker) can be applied to indicate the point of treatment clearly in both imaging modalities and to localize and track tumors in real time. In this study, we present the development of a marker based on lactose octaacetate:octapropionate 1:1 containing 3 mM PLA-DTPA(Gd), 40% triglyceride, 5% propylene carbonate and 10% XSAIB (sucrose based CT-contrast agent). The injectable marker had high CT contrast (>；1000 HU) and displayed clearly visible, stable T1 contrast enhancement (T1˜0.900 ms) in the rim over at least 3 weeks with clinically observable resolution.
