The device for manufacturing percutaneous absorption gas is characterized: in being provided with a carbon dioxide supply unit for supplying gaseous carbon dioxide, a solvent vapor-generating unit for generating vapor of a solvent that is capable of solubilizing carbon dioxide and is vaporizable, and a percutaneous absorption gas-generating unit for mixing the supplied carbon dioxide with the generated solvent vapor to generate the percutaneous absorption gas, which comprises the gaseous carbon dioxide-solvent complex; and in also being provided with a floating droplet removal unit for removing floating droplets of the solvent from the percutaneous absorption gas that has been generated.一種經皮吸收用氣體製造裝置,包括:用以供應氣體狀二氧化碳至該裝置內之二氧化碳供應部;用以生成能溶解二氧化碳且為氣化性之溶媒蒸汽之溶媒蒸汽生成部;用以將供應之二氧化碳與生成之溶煤蒸汽混合而生成含有氣體狀二氧化碳溶媒複合體之經皮吸收用氣體之經皮吸收用氣體生成部;且進一步包括用以從生成之經皮吸收用氣體去除溶煤之浮遊液滴之浮油液滴去除部,或者用以防止溶媒之浮遊液滴混入生成之經皮吸收用氣體內之防止液滴混入裝置為其特徴。本發明也包括使用上述製造裝置以製造經皮吸收用氣體之方法。