PHARMACEUTICAL FORMULATION CONTAINING LIPOSOME NANOPARTICLES THAT ENCAPSULATE POORLY WATER SOLUBLE DRUG HAVING GOOD LONG STABILITY AND PREPARATION METHOD THEREOF
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;한국화학연구원
发明人:
CHO, SUN HANG,조선행,SHIN, BYUNG CHUL,신병철,SON, YEO WON,손여원,SUNG, HA SOO,성하수,CHOI, YOUN WOONG,최연웅,YUK, SOON HONG,육순홍,CHOA, SANG MIN,조상민,CHO, SUN HANGKR,SHIN, BYUNG CHULKR,SON, YEO WONKR,SUNG, HA SOOKR,CHOI, YOUN WOONGKR,YUK, SOON HONGKR,CHOA, SANG MINKR
申请号：
KR1020130146061
公开号：
KR1020150062204A
申请日:
2013.11.28
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a pharmaceutical medicine with excellent long-term stability comprising liposome nanoparticles-encapsulated poorly water soluble drugs and a manufacturing method thereof. According to the present invention, the size of liposome nanoparticles-encapsulated poorly water soluble drugs is from 30 to 900 nm, and a pharmaceutical medicine comprising the same improves solubility and bioavailability of the medicine with excellent long-term stability. In addition, the pharmaceutical medicine can be manufactured with an easy manufacturing method, thus can be applied for poorly water soluble drugs required for stability.본 발명은 본 발명은 난용성 약물이 봉입된 리포좀 나노입자를 포함하는 장기 안정성이 우수한 약학적 제제 및 이의 제조방법에 관한 것으로써,본 발명에 따른 난용성 약물이 봉입된 리포좀 나노입자 크기는 30-900 nm로 이를 포함하는 약학적 제제의 용해도를 향상시키고, 장기 안정성이 우수하므로, 약물의 생체이용률을 향상시킬 수 있다. 또한, 상기 약학적 제제는 용이한 제조방법으로 제조할 수 있으므로 안정성이 필요한 난용성 약물에 유용하게 적용할 수 있다.
