Pharmaceutically acceptable salt of 6-carboxy-2-(3,5 dichlorophenyl)-benzoxazole, and a pharmaceutical composition comprising the salt thereof

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专利权人:

Evan T. Powers;Jeffery W. Kelly;Hossein Razavi

发明人:

Jeffery W. Kelly,Evan T. Powers,Hossein Razavi

申请号：

US12481527

公开号：

US08168663B2

申请日:

2009.06.09

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods are disclosed.

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