COMPOSITIONS AND METHODS FOR PROBING AND/OR CONTROLLING BIOCHEMICAL MECHANISMS RELATING TO PROCESS OF BLOOD COAGULATION AND HUMORAL IMMUNITY, FOR INVESTIGATING AND/OR MODULATING SAID PROCESSES FOR HEALTH APPLICATIONS
CAOILI, Salvador Eugenio C.,CLIMACOSA, Fresthel Monica M.,KING, Ruby Anne N.,SANTOS, Bobbie Marie M.
申请号：
PH12018050480
公开号：
PH12018050480A1
申请日:
2018.10.17
申请国别(地区):
PH
年份:
2020
代理人:
摘要：
The invention provides: macromolecular peptide-based constructs comprising fibrin(ogen)-, heparin- and/or microbe-binding motifs, said constructs exemplified by polymeric peptide-based constructs and supramolecular constructs comprising immune complexes； use of said constructs for modulating blood plasma coagulation activity in the presence or absence of heparin, detecting microbes, enhancing antibody-mediated immune clearance of said microbes and/or stabilizing cell membranes； modified erythrocytes comprising inactivated anticomplement defense systems； methods for making said erythrocytes； use of said erythrocytes for detecting said complement activity； compositions comprising functional blood plasma proteins and chemically inactivated complement components； methods for making said compositions using nucleophilic agents； and use of said constructs and/or compositions in methods for treating conditions characterized by coagulopathy and/or complement-mediated pathology.
