COMPOSITIONS AND METHODS FOR PROBING AND/OR CONTROLLING BIOCHEMICAL MECHANISMS RELATING TO PROCESS OF BLOOD COAGULATION AND HUMORAL IMMUNITY, FOR INVESTIGATING AND/OR MODULATING SAID PROCESSES FOR HEALTH APPLICATIONS
CAOILI, Salvador Eugenio C.,CLIMACOSA, Fresthel Monica M.,KING, Ruby Anne N.,SANTOS, Bobbie Marie M.
申请号:
PH12018050480
公开号:
PH12018050480A1
申请日:
2018.10.17
申请国别(地区):
PH
年份:
2020
代理人:
摘要:
The invention provides: macromolecular peptide-based constructs comprising fibrin(ogen)-, heparin- and/or microbe-binding motifs, said constructs exemplified by polymeric peptide-based constructs and supramolecular constructs comprising immune complexes; use of said constructs for modulating blood plasma coagulation activity in the presence or absence of heparin, detecting microbes, enhancing antibody-mediated immune clearance of said microbes and/or stabilizing cell membranes; modified erythrocytes comprising inactivated anticomplement defense systems; methods for making said erythrocytes; use of said erythrocytes for detecting said complement activity; compositions comprising functional blood plasma proteins and chemically inactivated complement components; methods for making said compositions using nucleophilic agents; and use of said constructs and/or compositions in methods for treating conditions characterized by coagulopathy and/or complement-mediated pathology.