BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH
发明人:
POHL JENS,PLOGER FRANK,KRUSE MICHAEL
申请号：
SI200631358
公开号：
SI1948689T1
申请日:
2006.11.17
申请国别(地区):
SI
年份:
2012
代理人:
摘要：
The application relates to novel biosynthetic growth factor mutants, derived from GDF-5, which exhibit improved biological activity. Mutations at positions 453 and 456 of human GDF-5 are disclosed, as well as use of these mutants in therapy of diseases associated with tissue degeneration/destruction.
