A multi-bottle infusion apparatus provided with multiple medicine-changing apparatus (9, 38, and 39). When a patient needs multiple medicinal solutions for an infusion therapy, a nurse utilizes the medicine-changing apparatus (9, 38, and 39) for connection between medicinal solution packs (10, 16, 17, and 37). Each of the medicine-changing apparatus (9, 38, and 39) is provided with a manual valve (13) controlled by utilizing a drawstring (23). When the medicinal solution of a first medicinal solution pack is depleted, either the patient or an accompanying person utilizes the drawstring (23) to pull the manual valve (13) to place the medicinal solution of a subsequent bottle of medicinal solution pack into a preceding bottle of medicinal solution pack, thus solving the problem of nurse shortage. Also (incorporated by reference), a multi-bottle infusion apparatus provided with a medicine-changing valve (9). When a patient needs multiple medicinal solutions for an infusion therapy, a nurse connects penetrating connectors (8) of the medicine-changing apparatus (7) to medicinal solution bottles (24). When the medicinal solution of a first medicinal solution bottle (24) is depleted, either the patient or an accompanying person rotates a handwheel (21) of the medicine-changing valve (9) to make an infusion bottle pointer (22) thereof to be aligned with an infusion bottle label (23) corresponding thereto, and utilizes a solution-guiding hole (17) of a rotating valve core (12) to connect the medicinal solution of a subsequent medicinal solution bottle (24) to a solution-infusing apparatus (1), thus solving the problem of nurse shortage.Linvention concerne un appareil de perfusion à plusieurs bouteilles muni de multiples appareils de changement de médicament (9, 38 et 39). Lorsquun patient a besoin de plusieurs solutions médicamenteuses pour une thérapie par perfusion, un infirmier utilise lappareil de changement de médicament (9, 38 et 39) pour établir une connexion entre de