ベンゾチオフェン化合物、該化合物を有効成分とするオルタナティブオートファジー誘導剤及び抗癌剤、並びに抗癌活性を有する化合物をスクリーニングするための方法

• 收藏
• 分享

专利权人:

国立大学法人 東京医科歯科大学

发明人:

清水 重臣,細谷 孝充,室橋 道子,吉田 優

申请号：

JP20130557579

公开号：

JP6124409(B2)

申请日:

2013.02.07

申请国别(地区):

日本

年份:

2017

代理人:

摘要：

It has been found that efficient screening for a compound having anticancer activity can be achieved by selecting a compound having activity to induce alternative autophagy using, as an index, formation of fluorescent bright spots due to aggregation of a lysosomal protein to which a fluorescent protein is attached in cells expressing the lysosomal protein. In addition, it has been found that a benzothiophene compound represented by the following general formula (1) has alternative autophagy-inducing activity and anticancer activity:

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/