PROBLEM TO BE SOLVED: To provide a method for generating, within a living body of a nonhuman animal, the organ of a mammal having a complicated cellular composition composed of cells of a plurality of species, such as kidney, pancreas, thymus gland, and hair.SOLUTION: A method for generating a kidney, pancreas, thymus gland, and hair newly by applying a chimeric animal assay to a novel generation method of solid organs, specifically, by rescuing, using blastocyst complementation, a model mouse defective in the kidney, pancreas, thymus gland, and hair attributed to the dysfunction of metanephric mesenchyme differentiating to the most of mature kidney.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】腎臓、すい臓、胸腺及び毛などの複数種の細胞からなる複雑な細胞構成を有する哺乳動物の臓器を、非ヒト動物の生体中で作成する方法の提供。【解決手段】キメラ動物・アッセイを、固形臓器の新規作製方法に応用し、具体的には、前記キメラ動物・アッセイを、成体腎臓の大部分へ分化する後腎間葉の機能異常により腎臓、すい臓、胸腺及び毛が欠損するモデルマウスを、胚盤胞補完作用によりレスキューすることにより、新規に腎臓、すい臓、胸腺及び毛を製造する方法。【選択図】なし
