PROBLEM TO BE SOLVED: To provide a method for producing a mammalian organ which has a complicated cell composition consisting of two or more kinds of cells, such as kidney, pancreas, thymus, and hair, in a living body of a non-human animal.SOLUTION: The invention provides a method for newly producing kidney, pancreas, thymus, and hair by applying a chimeric animal assay to a novel production method of a solid organ, and rescuing, with a blastocyst complement action, a kidney, pancreas, thymus, and hair deficient model mouse due to dysfunction of metanephric mesenchyme which differentiates into most of an adult kidney.COPYRIGHT: (C)2015,JPO&INPIT【課題】腎臓、すい臓、胸腺及び毛などの複数種の細胞からなる複雑な細胞構成を有する哺乳動物の臓器を、非ヒト動物の生体中で作成する方法の提供。【解決手段】キメラ動物・アッセイを、固形臓器の新規作製方法に応用し、キメラ動物・アッセイを、成体腎臓の大部分へ分化する後腎間葉の機能異常により腎臓、すい臓、胸腺及び毛が欠損するモデルマウスを、胚盤胞補完作用によりレスキューすることにより、新規に腎臓、すい臓、胸腺及び毛を製造する方法。【選択図】なし
