A tissue biopsy device for accessing and collecting a tissue specimen from a target site within a patient, comprising:a. a drive housing which has a plurality of drive units；b. an outer member which is releasably secured to the drive housing, which has a proximal tubular portion, which has an inner lumen extending within the proximal tubular portion, which has a tissue penetrating distal tip, which has an open section proximal to the tissue penetrating distal tip and which has a supporting strut extending from the penetrating distal tip to the proximal tubular portion；c. a tissue accessing cannula which is slidably disposed at least in part within the inner lumen of the proximal tubular portion of the outer member, which has an inner lumen extending therein, and which has a tissue receiving aperture spaced proximal to the distal end thereof in fluid communication with the inner lumen of the accessing cannula and which is operably secured to a drive unit in the drive housing to rotate the tissue receiving cannula to adjust the orientation of the tissue receiving aperture ； andd. an elongated tissue cutting member which is formed at least in part of a tubular member, which is slidably disposed within the inner lumen of the tissue accessing cannula, which has a tissue cutting edge, which has an inner lumen extending therein configured to receive a tissue specimen cut by the tissue cutting member, and which is connected to a drive unit to move the tissue cutting member within the inner lumen of the tissue accessing cannula.
