A system and method of disinfecting an area using germicidal radiation. The system is configured to capture images of an environment, analyze the images to determine locations of a person or unprotected skin of a person in the environment, and control one or more germicidal radiation emitters to decontaminate the environment where the person or exposed skin of persons in the environment are not located. The system and method allow for safe decontamination of an environment using hazardous levels of germicidal radiation while occupied by a person who may not be fully protected from the radiation.