PROBLEM TO BE SOLVED: To provide compositions for targeted controlled drug release, used for treating or imaging vascular stenosis, stenotic lesions, occluded lumens, embolic phenomena, thrombotic disorders, and internal hemorrhage.SOLUTION: There is provided an aggregate comprising a therapeutic agent and the like, and comprising a plurality of nanoparticles such as liposomes, where the aggregate disaggregates under a predetermined stimulus selected from the group consisting of the ultrasound, mechanical strain, vibration, magnetic field, radiation, temperature, ionic strength, pH, pressure, turbulence, change in flow, flow rate, and chemical or enzymatic activation.SELECTED DRAWING: None【課題】血管狭窄症、狭窄性病変、閉塞管腔、塞栓現象、血栓障害、および内出血を治療または画像化するために用いる、薬物の標的指向性制御放出組成物の提供。【解決手段】治療薬等を含み、超音波、機械的歪み、振動、磁場、照射、温度、イオン強度、pH、圧力、乱流、流量の変化、流速、または化学的もしくは酵素的活性化からなる群より選択される所定の刺激を受けて脱凝集する複数のリポソーム等のナノ粒子を含む凝集体。【選択図】なし
