<;P>;PROBLEM TO BE SOLVED: To provide a knockout nonhuman animal or the like, usable for screening a remedy for arteriosclerosis. <;P>;SOLUTION: There is provided the knockout nonhuman animal or a part thereof from which functions of the whole or a part of LDLR gene, and the whole or a part of at least one gene selected from the group consisting of EBI3 gene, IL27-p28 gene and WSX-1 gene are deleted. <;P>;COPYRIGHT: (C)2011,JPO&INPIT