Lanthionine ketimine derivatives, and methods of making and using the same, are described. Included are lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P) derivatives, as well as lanthionine ketimine derivatives having a tert-enamide moiety at the 2-position (NVP-LKE).Linvention concerne des dérivés de lanthionine-cétimine et des procédés de fabrication et dutilisation de ceux-ci. Linvention concerne lanthionine-cétimine phosphonate (LK-P), des dérivés de lanthionine-cétimine ester phosphonate (LKE -P) ainsi que des dérivés de lanthionine-cétimine ayant une fraction tert-énamide en position 2 (NVP-LKE).