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AQUEOUS OPHTHALMIC SUSPENSION OF CRYSTALLINE REBAMIPIDE
专利权人:
OTSUKA PHARMACEUTICAL CO.; LTD.
发明人:
ISHIKAWA, SHINICHI,TOMOHIRA, YUSO,HIRAOKA, SHOGO,MATSUDA, TAKAKUNI
申请号:
ARP170101857
公开号:
AR108955A2
申请日:
2017.07.05
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
This Hair Ming Department Ti contain the Yan System product of Rebamipide Gong Yi Seed, and what is using the upper pH value with the transparency for it is to be enough receiving and neutral acidity on the weak side, and Hui Injury evils do not suffer from the sufferer Jiao Qualityization Knot films of universe eye disease. The ophthalmically acceptable Hanging Fu Ye Department of liquid of Han Knot crystal form Rebamipides are added in acidic aqueous solution by the aqueous solution of Will Rebamipides and are mixed to provide the transparency of improvement, wherein, The acidic aqueous solutions As is for example containing the compound Which acid Zhi Shao mono- Seed Election from water-soluble polymer and interfacial activity Elixirs, and for example Hydrogen Yangization Na Come dissolve the aqueous solution of Rebamipide or the aqueous solution of auspicious bar of Pi Te Which to the Shui Rong Ye The Shi Yi Alkaline of The Rebamipides.本發明係提供一種含瑞巴匹特之眼用製品,其於使用上具有足以令人接受之透明度以及中性偏弱酸性之pH值,不會傷害罹患乾眼症之病患的角質化結膜。含結晶型瑞巴匹特之液態眼用懸浮液係藉由將瑞巴匹特之水溶液加至酸性水溶液中混合以提供改良的透明度,其中,該酸性水溶液為譬如含有至少一種選自水溶性聚合物和界面活性劑之化合物的鹽酸,而該瑞巴匹特之水溶液則是以鹼譬如氫氧化鈉來溶解瑞巴匹特之水溶液或瑞巴匹特鹽之水溶液。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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