The present invention, schizophrenia, obsessive-compulsive personality disorder, depression, bipolar disorder, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder , Parkinsons disease, dementia, Alzheimers disease, mild cognitive impairment, chemotherapy-induced cognitive impairment ( "Kemoburein"), downs syndrome, autism spectrum disorder, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis disease, multiple sclerosis, Huntingtons disease, stroke, as well as disorders caused by radiation therapy, chronic stress, optic nerve disorders or macular degeneration, or nerve stimulation drugs, such as alcohol, opiates, methamphetamine, addiction of phencyclidine or cocaine in for treatment, the general formula I [formula, R 1 is halogen, optionally substituted cyano, or lower alkyl substituted by halogen, is phenyl or pyridinyl or dihydro - be a pyran-4-yl R 2 is hydrogen or lower alkyl R 3 is lower alkoxy or S (O) 2 - is optionally substituted by lower alkyl, - (CHR) n - is phenyl, or is optionally substituted by = O, and lower alkyl , or heterocycloalkyl, or optionally substituted lower alkyl, - is (CH 2 ) n -5 or 6 membered heteroaryl or hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy, -NR-S (O) 2 - lower alkyl, - (CH 2 ) n - cycloalkyl or - (CH 2 ) n -S (O) 2 - or a lower alkyl or, R 2 and R 3 , together with which they are attached N- atom, 1,1 dioxo - thiomorpholinyl, morpholinyl, or is selected from the group consisting of pyrrolidinyl optionally substituted with hydroxy, forms a heterocycloalkyl ring R is hydrogen or lower alkyl n is 0, 1 or a compound represented by 2 is, pharmaceutically acceptable acid addition salts of certain iso, racemic mixture, or the use of the corresponding enantiomers and / or optical isomers thereof.本発明
