ZHOU, MINGXING,DADEY, ERIC,ZHOU, Mingxing,DADEY, Eric
申请号：
RSP20150211
公开号：
RS53890B1
申请日:
2005.11.10
申请国别(地区):
RS
年份:
2015
代理人:
摘要：
The invention relates to a delivery system for the sustained and controlled delivery of a group of bioactive agents. More particularly, the invention relates to a delivery system and a method for delivery of a bioactive agent containing a nucleophilic functional group by means of a biodegradable, sustained-release implant. The implant may be a preformed implant, microparticles or an in situ formed implant. The implant includes a biodegradable thermoplastic polymer, the bioactive agent having a nucleophilic group substituent and a stabilizing associate as well as other optional components. The combination of the stabilizing associate with the bioactive agent prevents and/or minimizes and/or lessens degradation of the thermoplastic polymer by the bioactive agent.Kompozicija za upotrebu kao formulacija sa kontrolisanim oslobađanjem koja sadrži biološki razgradiv, biokompatiban, termoplastičan polimer, pomoćno sredstvo za stabilizaciju koje uključuje polikarboksilnu kiselinu, polifosfornu kiselinu, ili polisulfonsku kiselinu, nukleofilno bioaktivni agens, dodatno uključuje organsku tečnost, pri čemu je kompozicija, fluidna kompozicija bez prethodno formiranih čvrstih oblika. Prijava sadrži još 13 patentnih zahteva.
