A biocompatible implant (I1) comprising a biocompatible scaffold, and at least one tissue fragment associated with at least a portion of the scaffold, is new. The tissue fragment includes viable cells that can migrate out of the tissue fragment and populate the scaffold. Independent claims are also included for: (1) a biocompatible implant (I2) comprising a biocompatible scaffold, a suspension containing at least one cartilage tissue fragment associated with at least a portion of the scaffold, and a retaining element (the tissue fragment contains viable cells that can migrate out of the tissue fragment and populate the scaffold)； (2) a kit comprising a sterile container containing at least one biocompatible scaffold, and a harvesting tool for collecting at least one viable tissue sample from a subject； (3) preparing the tissue implant (I1) involving: (a) processing a tissue under aseptic conditions to form the tissue fragment and a physiological buffering solution； and (b) depositing the tissue fragment on the bioimplantable scaffold； and (4) measuring the effect of a substance on living tissue involving: (a) creating a tissue construct by processing the tissue sample to form the tissue fragment, depositing the tissue fragment on the biocompatible scaffold such that the tissue fragment is associated with the biocompatible scaffold； and incubating the tissue construct for a duration and under conditions effective to allow cells within the tissue fragment to populate the scaffold； (b) contacting the tissue construct with a substance； and (c) determining the effects of the substance on the tissue construct (the substance is selected from a drug, a pharmaceutical composition, a chemical, a microbe, an element, a cytokine, a growth factor, a hormone, an antibody, a peptide, a ligand and/or an antagonist of membrane-bound receptor). ACTIVITY : Osteopathic. MECHANISM OF ACTION : Tissue repair and/or regeneration inducer.
