Benjamin Elliott Mead,Lauren Levy,Daphne Sze,Robert Samuel Langer, Jr.,Jeffrey Michael Karp,Kazuki Hattori,Alexander Kann Shalek
申请号：
US16698513
公开号：
US20200237852A1
申请日:
2019.11.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Leucine-rich repeat-containing G-protein coupled receptor 5-positive (LGR5+) intestinal cells are contacted with an inhibitor of exportin 1 (XPO1), thereby producing functionally differentiated intestinal cells. The LGR5+ cells can also be contacted with a Wnt agonist. The LGR5+ cells can also be contacted with a Notch inhibitor.
