Substituted N-heteroaryltetrahydro-isoquinoline derivatives, their preparation and therapeutic use

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专利权人:

サノフイ

发明人:

ジョンリー・ガオ,ライアン・ハートゥング

申请号：

JP2013510223

公开号：

JP5784110B2

申请日:

2011.05.10

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The present disclosure relates to a series of substituted N-heteroaryl tetrahydro-isoquinoline derivatives of formula (I). wherein R, R1, R2, X, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this disclosure also relates to methods of preparation of substituted N-heteroaryl tetrahydro-isoquinoline derivatives of formula (I) and intermediates therefor.

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