Michio Ichimura;Shinichi Ide;Yuji Nomoto;Robert M. Scarborough;Junko Sasaki;Anjali Pandey;Eiji Tsukuda;Kenji Matsuno;Shoji Oda
发明人:
Anjali Pandey,Robert M. Scarborough,Kenji Matsuno,Michio Ichimura,Yuji Nomoto,Shinichi Ide,Eiji Tsukuda,Junko Sasaki,Shoji Oda
申请号：
US12471280
公开号：
US08324205B2
申请日:
2009.05.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
