The U.S.A. as represented by the Secretary, Department of Health and Human Services;Advaxis, Inc.; Inc.;Advaxis
发明人:
PETIT, Robert,WALLECHA, Anu,KHLEIF, Samir,CHEN, Zhisong,BERZOFSKY, Jay A.
申请号：
EP15821743
公开号：
EP3169355A4
申请日:
2015.07.17
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention is directed to compositions comprising an immune checkpoint inhibitor or a T cell stimulator or a combination thereof, and a live attenuated recombinant Listeria strain comprising a fusion polypeptide comprising a truncated Listeriolysin O protein, a truncated ActA protein, or a PEST amino acid sequence fused to a tumor-associated antigen. The invention is further directed to methods of treating, protecting against, and inducing an immune response against a tumor or a cancer, comprising the step of administering the same.
