DOSING REGIMENS AND DOSAGE FORMS FOR TARGETED TGF-B INHIBITION

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专利权人:

MERCK PATENT GMBH

发明人:

DUSSAULT, Isabelle,EL BAWAB, Samer,VUGMEYSTER, Yulia,KHANDELWAL, Akash

申请号：

SG11201906157Y

公开号：

SG11201906157YA

申请日:

2018.01.05

申请国别(地区):

SG

年份:

2019

代理人:

摘要：

• () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 July 2018 (12.07.2018) WIP0 1 PCT IiiimmoimiolollmonolomomommllnommiovoimIE (10) International Publication Number WO 2018/129331 Al (51) International Patent Classification: A61K 39/395 (2006.01) C07K 16/46 (2006.01) A61P 35/00 (2006.01) CO7K 19/00 (2006.01) C07K 14/495 (2006.01) C12N 15/13 (2006.01) (21) International Application Number: PCT/US2018/012604 (22) International Filing Date: 05 January 2018 (05.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/443,698 07 January 2017 (07.01.2017) US 62/581,978 06 November 2017 (06.11.2017) US (71) Applicant: MERCK PATENT GMBH [DE/DE]； Frank- furter Strasse 250, 64293 Darmstadt (DE). (72) Inventor； and (71) Applicant: DUSSAULT, Isabelle [US/US]； 620 Central Avenue, Needham, MA 02494 (US). (72) Inventors: EL BAWAB, Samer； Romischer Ring 5, 60486 Frankfurt Am Amin (DE). VUGMEYSTER, Yu- lia； 90 Hemingway Street, Winchester, MA 01890 (US). KHANDELWAL, Akash； August Bebel Strasse 61, 64347 Griesheim (DE). (74) Agent: ASHRAF, Shovon et al.； Goodwin Procter LLP, 100 Northen Avenue, Boston, MA 02210 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM

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