Indiana University Research and Technology Corporation
发明人:
DiMarchi, Richard D,Kou, Binbin
申请号：
BRPI0922969
公开号：
BRPI0922969A2
申请日:
2009.12.18
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
