Filtration devices, methods, and systems comprising a decontamination filtration medium. The filtration medium comprises a remotely-triggered decontamination material stored in microcapsules that are embedded in or attached to a filter element. The microcapsules contain a decontamination agent that will detoxify one or more toxins, including but not limited to chemical and biological warfare agents, and industrial materials and chemicals, among other things. The microcapsules can be locally or remotely triggered to release the detoxifying agent by a triggering agent such as light, electrical potential, pressure, temperature, or other methods. One method of use of the filtration device comprises the following: when a target toxin is detected in the vicinity of the device, the microcapsules are actively triggered to release the detoxifying agent, thereby neutralizing the toxic agent.