ANTIBODIES AND CONJUGATES THAT TARGET MISFOLDED PRION PROTEIN

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专利权人:

Amorfix Life Sciences Ltd.;Helix BioPharma Corp.

发明人:

Marni Diane Uger,Viengthong Chai,Veronica Ciolfi,Neil R. Cashman,Baomin Tian,Wah Yau Wong,Heman Lap-Man Chao

申请号：

US14407724

公开号：

US20150166668A1

申请日:

2013.06.11

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Human prion protein, PrP, selectively presents the epitope MDEYSNQNN (SEQ ID No. 14) when PrP misfolds. The misfolded form of human PrP is associated with various disease states. The present invention provides an antibody useful to detect and treat such diseases, including cancer such as ovarian cancer and lymphomas, and transmissible spongiform encephalopathies such as CJD. Also provided is an immunoconjugate in which the antibody is conjugated with urease as cytotoxin.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/