BLANCHETOT, CHRISTOPHE,DE HAARD, JOHANNES,DREIER, TORSTEN,DE JONGE, NATALIE,VAN DER WONING, SEBASTIAN PAUL,ONGENAE, NICOLAS
申请号：
PE0019132014
公开号：
PE03352015A1
申请日:
2013.05.23
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
The present Invention provides binding molecules (e.g., Antibodies or Antigen binding Fragments thereof that specifically bind to and inhibit the Biological activity of IL - 6 (e.g. Human IL - 6, IL - 6, IL - 6 Mouse and nonhuman primate nonhuman).In a Preferred embodiment, the Antibodies or Antigen binding Fragments of the invention bind to il-6 and inhibit its binding to a receptor for il-6. Such Antibodies or Antigen binding Fragments are particularly useful for the treatment of diseases or Disorders associated with il-6 (For example, inflammatory diseases and cancer.La presente invencion proporciona moleculas de union (por ejemplo, anticuerpos o fragmentos de union a antigeno de los mismos) que se unen especificamente a e inhiben la actividad biologica de IL-6 (por ejemplo, IL-6 humana, IL-6 de raton e IL-6 de primate no humano no humano). En una realizacion preferida, los anticuerpos o fragmentos de union a antigeno de la invencion se unen a la IL-6 e inhiben su union a un receptor de IL-6. Tales anticuerpos o fragmentos de union a antigeno son particularmente utiles para el tratamiento de enfermedades o trastornos asociados a IL-6 (por ejemplo, enfermedades inflamatorias y cancer)
