Described herein are methods of treating dry eye disease, increasing tear production, or reducing ocular discomfort in an individual with compound 1 having the structure,or a pharmaceutically acceptable salt thereof. The method comprises the effective treatment of the individual indicated by a statistically significant improvement in one or more eye test scores. The present disclosure also describes a method for immediate and long-term pharmacological stimulation of a nicotinic acetylcholine receptor with compound 1, or a pharmaceutically acceptable salt thereof.本文描述使用具有以下結構之化合物1，或其醫藥學上可接受之鹽對個體治療乾眼病、增加淚液產生或減少眼部不適之方法。該方法包含由一或多種眼睛測試評分之統計上顯著改善指示該個體之有效治療。本發明亦描述一種用化合物1或其醫藥學上可接受之鹽對菸鹼乙醯膽鹼受體進行立即及長期藥理學刺激之方法。
