The medicine composition in order it prevents or to remedy the passing activity bladder which accompanies nervous obstacle is offered. The Indian phosphorus derivative which is displayed with below-mentioned general formula (i) or that the medicine composition which contains the salt which is allowed pharmacology as the active ingredient. The said medicine composition brain blood vessel obstacle, is useful in prevention or remedy of the passing activity bladder which accompanies nervous obstacle such as the parkinsons disease and spinal cord obstacle. As for R in formula the substitution yes aliphatic acyl basis, as for R such as substitution yes low-grade alkyl group and the substitution yes aromatic acyl basis1 the cyano basis or the karubamoiru basis, as for R2 the substitution yes low-grade alkyl group is displayed.神経障害に伴う過活動膀胱を予防又は治療するための医薬組成物を提供する。下記一般式(I)で表されるインドリン誘導体またはその薬理学的に許容される塩を有効成分として含有する医薬組成物。該医薬組成物は、脳血管障害、パーキンソン病、脊髄障害等の神経障害に伴う過活動膀胱の予防又は治療に有用である。式中のRは置換可脂肪族アシル基、置換可低級アルキル基、置換可芳香族アシル基等、R1はシアノ基又はカルバモイル基、R2は置換可低級アルキル基を表す。
