A system and method for generating time-resolved 3D medical images of a subject includes acquiring a time series of two-dimensional (2D) data sets from a portion of the subject using a magnetic resonance imaging (MRI) system and reconstructing the time series of 2D data sets into a 2D time series of images of the subject having a given frame rate. The process also includes acquiring a time-independent, 3D volume of the portion of the subject and combining the 2D time series of images of the subject with the time-independent 3D volume of the subject to generate a set of time-dependent 3D volume images of the portion of the subject at the given frame rate.
